6·î14Æü¤Î¡Ö¥¬¥ó¼£ÎŤȵ¾À·¡×¤Ç¡¢
¤½¤ì¤ò¼õ¤±¤Æ¡¢
6·î15Æü¤Ë
¤¹¤Ù¤Æ¤ÎÂåÂØÎÅË¡¤¬¡¢ÌµÂ̤À¤È¤Ï»×¤Ã¤Æ¤¤¤Þ¤»¤ó¡£
µÕ¤Ë¡¢¥¬¥ó¤Î¼ïÎà¤ä¼£ÎÅ¤ÎÆâÍÆ¤Ë¤è¤Ã¤Æ¤Ï¡¢
ɸ½àŪ¹³´âºÞ¼£ÎŤò¼õ¤±¤ë¤¯¤é¤¤¤Ê¤é¤Ð¡¢
ÂåÂØÎÅË¡¤ÎÊý¤¬¥Þ¥·¡£
¤È¹Í¤¨¤ë¤³¤È¤â¤¢¤ë¤¯¤é¤¤¤Ç¤¹¡£
ÂåÂØÎÅË¡¤ÎÌäÂê¤Ï¡¢
2·î12Æü¤Î¡Ö¥¤¥ó¥Á¥Ìȱּ£ÎÅ¥¯¥ê¥Ë¥Ã¥¯¡×
1·î24Æü¤Î¡Ö·ò¹¯¿©ÉʤˤĤ¤¤Æ¡×
1·î22Æü¤Î¡ÖÌȱּ£ÎšפʤɤǤâ½ñ¤¤Þ¤·¤¿¤¬¡¢
¤¢¤¿¤«¤â¿Âç¤Ê¼£ÎŸú²Ì¤¬¤¢¤ë¤«¤Î¤è¤¦¤ËÀëÅÁ¤·¤Æ¡¢
Ë¡³°¤Ê¼£ÎÅÈñ¤òÀÁµá¤¹¤ë¿ÇÎŽê¤Î¸ºß¤Ç¤¹¡£
¥¬¥ó¥Ó¥¸¥Í¥¹¤Ë¤Ò¤¿Áö¤Ã¤Æ¤¤¤ëÇÚ¤¬¤¤¤ë¤³¤È¤Ç¤¹¡£
´µ¼Ô¤µ¤ó¤Î°Õ¼±¤È¤·¤Æ¤Ï¡¢
¡Ö¿³Û¤Î¼£ÎÅÈñ¤ò»Ùʧ¤¨¤Ð¡¢¤½¤Îʬ¤µ¤¾Â礤ʸú²Ì¤¬´üÂԤǤ¤ë¤Î¤Ç¤Ï¤Ê¤¤¤«¡×
¤È¹Í¤¨¤Æ¤·¤Þ¤¦¤Î¤Ç¤Ï¤Ê¤¤¤Ç¤·¤ç¤¦¤«¡£
¤·¤«¤·¡¢¤½¤ÎÍͤʤ³¤È¤Ï¤¢¤ê¤Þ¤»¤ó¡£
5·î19Æü¤Î¡Ö¥À¥á¤â¤È¼£ÎŤȤϡ©¡×¤Ç½ñ¤¤Þ¤·¤¿¤¬¡¢
¸½ºß¤Îɸ½àŪ¹³´âºÞ¼£ÎŤ½¤Î¤â¤Î¤¬¡¢
º¬¼£ÉÔǽ¤Î¥¬¥ó¤ËÂФ·¤Æ¤Ï¡¢
¡Ö¥À¥á¤â¤È¼£ÎšפΤ褦¤Ê¤â¤Î¤Ç¤¹¡£
¤·¤«¤·¡¢É¸½àŪ¹³´âºÞ¼£ÎŤϡ¢
¥À¥á¤À¤Ã¤¿¾ì¹ç¡¢¡Ö¤â¤È¡×¤Ë¤Ï¤Ê¤ê¤Þ¤»¤ó¡£
ɸ½àŪ¹³´âºÞ¼£ÎŤǤϡ¢¥À¥á¤À¤Ã¤¿¾ì¹ç¡¢
½ÐȯÅÀ¡Ö¤â¤È¡×¤Ë¤ÏÌá¤ì¤Þ¤»¤ó¡£
¥Þ¥¤¥Ê¥¹ÅÀ¤«¤é¤ÎºÆ½Ðȯ¤Ë¤Ê¤ê¤Þ¤¹¡£
¤¢¤ë¤¤¤ÏºÆµ¯ÉÔǽ¤Ë¤Ê¤ê¤Þ¤¹¡£
¤½¤ì¤ò¹Í¤¨¤ì¤Ð¡¢
¥µ¥×¥ê¥á¥ó¥È¤òÍѤ¤¤¿ÂåÂØÎÅË¡¤Ï¡¢
¤½¤Î¡Ö¤ª»î¤·»þ´Ö¡×¤À¤±¤ò¸í¤ë¤³¤È¤Ê¤¯¡¢
¿¼Æþ¤ê¤·¤Ê¤±¤ì¤Ð¡¢
¥¼¥í¤«¤é¤ÎºÆ¥¹¥¿¡¼¥È¤¬²Äǽ¤Ç¤¹¤«¤é¡¢
¡Ö¥À¥á¤â¤È¡×¤Ç¤¢¤ê¡¢°¤¯¤Ï¤Ê¤¤¤È»×¤¤¤Þ¤¹¡£
»ä¼«¿È¤Ï¡¢ÂåÂØÎÅË¡¤Ï¹Ô¤Ã¤Æ¤¤¤ë¤Ä¤â¤ê¤Ï¤¢¤ê¤Þ¤»¤ó¤¬¡¢
¡Öɸ½àŪ¹³´âºÞ¼£ÎŤòÍ£°ìÀµÅö¤Ê¥¬¥ó¼£ÎšפÀ¤È¹Í¤¨¤Æ¤¤¤ë¥»¥ó¥»¥¤Êý¤«¤é¤ß¤ì¤Ð¡¢
»ä¤Î¡Öɸ½àŪ¤Ç¤Ï¤Ê¤¤¹³´âºÞ¼£ÎšפâÂåÂØÎÅË¡¤Î°ì¤Ä¤È¸«¤é¤ì¤Æ¤¤¤ë¤«¤â¤·¤ì¤Þ¤»¤ó¡£
¤Þ¤¿¡¢ÂåÂØÎÅË¡¤È¤Ï°ã¤¤¤Þ¤¹¤¬¡¢
ɸ½àŪ¤Ç¤Ï¤Ê¤¤¶Ë¾¯Î̤ι³´âºÞ¼£ÎŤò¹Ô¤Ê¤¦¤È¤¤Ë¡¢
ÌȱֳèÀ¤òÁý¶¯¤µ¤»¤ë¥µ¥×¥ê¥á¥ó¥È¤òÊ»ÍѤ¹¤ë¤³¤È¤Ë¤è¤Ã¤Æ¡¢
Â礤ʸú²Ì¤ò¤ß¤ë¤È¤¤¤¦¤³¤È¤Ï¡¢²¿²ó¤â·Ð¸³¤·¤Æ¤ª¤ê¤Þ¤¹¡£
¤Þ¤¿¡¢¥µ¥×¥ê¥á¥ó¥È¤¬²¿¸Î¤«¹³´âºÞ¼£ÎŤÎÉûºîÍѤò·Ú¸º¤¹¤ë¤È¤¤¤¦»ö¼Â¤Ï¡¢
¤·¤Ð¤·¤Ð·Ð¸³¤·¤Þ¤¹¡£
¤³¤ì¤Ï¡¢Â¾¤Îɱ¡¤Çɸ½àŪ¹³´âºÞ¼£ÎŤò¼õ¤±¤¿´µ¼Ô¤µ¤ó¤Î´¶ÁۤǤ¹¡£
¤½¤Î¥µ¥×¥ê¥á¥ó¥È¤¬´µ¼Ô¤µ¤ó¤Î·ÐºÑŪ¤ÊÉéô¤Ë¤Ê¤é¤Ê¤¤¤Î¤Ç¤¢¤ì¤Ð¡¢
¤±¤Ã¤·¤Æ°¤¯¤Ê¤¤¤È¹Í¤¨¤Æ¤¤¤Þ¤¹¡£
¼ÂºÝ¤Ë¥Ï¡¼¥»¥×¥Á¥ó¤ä´Ö¤â̵¤¯ÆüËܤǤâ½Ð¤Æ¤¯¤ë¥¢¡¼¥Ó¥¿¥Ã¥¯¥¹¤Ê¤É¤Ç¤Ï¡¢
ADCC¡ÊAntibody Dependent Cell Mediated Cytotoxity¡Ë
¹³Âΰ͸ÀºÙ˦¾ã³²ºîÍѤȤ¤¤¦¡¢
ÌȱֺÙ˦¤¬Â¸ºß¤·¤Æ¤Ï¤¸¤á¤Æ¹³¼ðáç¸ú²Ì¤òȯ´ø¤¹¤ë¤³¤È¤¬È½¤Ã¤Æ¤¤¤ëÌôºÞ¤â¤¢¤ê¤Þ¤¹¡£
¸½¼Â¤Ë¤Ï¥Ï¡¼¥»¥×¥Á¥ó¤ò»È¤¦¤È¤¡¢¤½¤ÎADCC³èÀ¤Ï¤Þ¤Ã¤¿¤¯¹Í褵¤ì¤º¡¢
ÌȱÖÎϤʤɴ°Á´¤Ë»¦¤·¤Æ¤·¤Þ¤¦Ç»Å٤ι³´âºÞ¤¬Ê»ÍѤµ¤ì¤Æ¤¤¤Þ¤¹¤¬¡¢
Ť¯À¸¤¤ë¡¢¤·¤«¤â¤Ä¤é¤¤»×¤¤¤ò¤·¤Ê¤¤¤³¤È¤ò¹Í¤¨¤ë¤È¡¢
¥Ï¡¼¥»¥×¥Á¥ó¤Î»È¤¤Êý¤Ï¡¢ºÆ¹Í¤ÎɬÍפ¬¤¢¤ë¤È»×¤Ã¤Æ¤¤¤Þ¤¹¡£
ÌÞÏÀ¡¢»ä¤Ï¥Ï¡¼¥»¥×¥Á¥ó¤âɸ½àŪ¤Ê¹³´âºÞ¤È¤ÎÊ»ÍѤϹԤʤäƤª¤ê¤Þ¤»¤ó¡£
¤³¤ì¤ò¡¢½ñ¤¯¤ÈŤ¯¤Ê¤ë¤Î¤Ç¸åÆü¤Ë¤·¤Þ¤¹¡£
¤Þ¤¿ºÇ¶á¤Ç¤Ï¡¢Ìȱ֤Ȥϴط¸¤Ê¤¤¤è¤¦¤Ç¤¹¤¬¡¢
¤¢¤ë¥µ¥×¥ê¥á¥ó¥È¤Ç¡¢¥¬¥ó¤ÎÁý¿£ÍÞÀ©¸ú²Ì¤¬¤¢¤ë¤«¤âÃΤì¤Ê¤¤¤³¤È¤¬È½¤ê¤Þ¤·¤¿¡£
¤Þ¤À¶Ë¤á¤ÆÉԳμ¤ʥǡ¼¥¿¤Ç¤¹¤¬¡¢
ËÜÅö¤ËÁý¿£ÍÞÀ©¸ú²Ì¤¬Ç§¤á¤é¤ì¤ë¤Î¤Ç¤¢¤ì¤Ð¡¢
͸ú¤Ê¼£ÎżêÃʤˤʤë²ÄǽÀ¤¬¤¢¤ê¤Þ¤¹¡£
º£¸å¤âÂåÂØÎÅË¡¤ò¹Ô¤Ã¤Æ¤¤¤¯¤Ä¤â¤ê¤Ï¤Þ¤Ã¤¿¤¯¤¢¤ê¤Þ¤»¤ó¤¬¡¢
͸ú¤Ç¤¢¤ê¡¢¿ÈÂΤ˳²¤¬¤Ê¤¤¡¢¤µ¤é¤Ë
·ÐºÑŪ¾ò·ï¤â´Þ¤á¤ÆQOL¤òÄã²¼¤µ¤»¤Ê¤¤¼£ÎŤǤ¢¤ì¤Ð¡¢
²¿¤Ç¤â¼è¤êÆþ¤ì¤Æ¤¤¤¯¤Ä¤â¤ê¤Ç¤¹¡£
»ä¤Ë¤È¤Ã¤Æ¤Î¥¨¥Ó¥Ç¥ó¥¹¤ÏÌܤÎÁ°¤Î´µ¼Ô¤µ¤ó°ì¿Í°ì¿Í¤¹¤Ù¤Æ¤Ç¤¹¡£
¡Ö¥¢¥á¥ê¥«¤ÇÂåÂØÎÅË¡¤¬À¹¤ó¡×¤È¤Î¤´»ØÅ¦¤Ç¤¹¤¬¡¢
»ä¤Ï¸½ºß¤Î¥¢¥á¥ê¥«¤Î¥¬¥ó¼£ÎŤξõ¶·¤ÏÃΤê¤Þ¤»¤ó¡£
¤·¤«¤·¡¢ÀèÆü½ªÎ»¤·¤¿ASCO¡ÊÊÆ¹ñÎ×¾²¥¬¥ó³Ø²ñ¡Ë¤Ç¤Ï¡¢
ÂåÂØÎÅË¡¤ÎÏÃÂ꤬½Ð¤Æ¤¤¤¿¤È¤Ïʹ¤¤¤Æ¤¤¤Þ¤»¤ó¡£
1987ǯ¤«¤é89ǯ¤Î2ǯ´Ö¸«¤Æ¤¤¿¥¢¥á¥ê¥«¤Î¥¬¥ó¼£ÎŤˡ¢
ÂåÂØÎÅË¡¤¬¹Ô¤ï¤ì¤Æ¤¤¤ë¤È¤¤¤¦Ïäâʹ¤¤¤¿¤³¤È¤Ï¤¢¤ê¤Þ¤»¤ó¡£
¤à¤·¤íÆüËÜ¤ÎÆüËÜ´â¼£Îųزñ¤Ç¤Ï¡¢
O¥¤¥ó¥Á¥Ìȱּ£ÎÅ¥¯¥ê¥Ë¥Ã¥¯¤ÎË¿¸µ¶µ¼ø¤¬¡¢
ÆüËÜ´â¼£Îųزñ¤òÀëÅÁ¤ËÍøÍѤ·¤Æ¤¤¤¿¤È¤¤¤¦»ö¼Â¤¬¤¢¤ê¡¢
°ìºòǯ¤«¤é¡¢°ìÀÚ¼è¤ê¾å¤²¤é¤ì¤Ê¤¯¤Ê¤ê¤Þ¤·¤¿¤¬¡¢
¤½¤ì¤Þ¤Ç¤Ï¡¢¥¢¥¬¥ê¥¯¥¹¤ä¡¢¥ê¥ó¥ÑµåÎÅË¡¤Ê¤É¤Î
ÂåÂØÎÅË¡¤Î±éÂ꤬Ëèǯ¤¿¤¯¤µ¤ó½Ð¤µ¤ì¤Æ¤¤¤Þ¤·¤¿¡£
ÂåÂØÎÅË¡¤Ï¡¢ÆüËܤÎÊý¤¬À¹¤ó¤Ê¤Î¤«¤âÃΤì¤Þ¤»¤ó¡£
²¿ÅÙ¤âÅö¥Ö¥í¥°¤Ç¤â»ØÅ¦¤·¤Æ¤¤¤ë¤È¤ª¤ê¡¢
¥¢¥á¥ê¥«¤Ï¡¢ÆüËܤȰåÎÅÀ©ÅÙ¤¬Â礤¯°ã¤¤¤Þ¤¹¡£
4000Ëü¿Í¤â¤¤¤ë̵Êݸ±¼Ô¤Ï¡¢
¼«Ê¬¤Î˾¤à°åÎŤϼõ¤±¤é¤ì¤Þ¤»¤ó¡£
¤½¤ÎÊý¡¹¤¬Î÷²Á¤ÊÂåÂØÎÅË¡¤ËÍê¤Ã¤Æ¤¤¤ë¤è¤¦¤Êµ¤¤¬¤·¤Þ¤¹¡£
¹³´âºÞ¼£ÎŤò̵Êݸ±¤Ç¹Ô¤Ê¤Ã¤¿¾ì¹ç¶Ë¤á¤Æ¹â³Û¤Ë¤Ê¤ê¤Þ¤¹¡£
ÆüËܤȤϻö¾ð¤¬°ã¤¦¤Î¤Ç¤Ï¤Ê¤¤¤Ç¤·¤ç¤¦¤«¡£
º£¤ÎÆüËܤÎÂåÂØÎÅË¡¤Ï¡¢Àè¤Û¤É¤Î¥¬¥ó¥Ó¥¸¥Í¥¹¤ÎÌäÂê¡£
¹¹¤Ë¿¼¹ï¤Ê¤Î¤Ï4·î30Æü¤Î¡Ö¥Û¥á¥ª¥Ñ¥·¡¼¡©¡×¤Ç¤â½ñ¤¤¤¿¤È¤ª¤ê¡¢
ÂåÂØÎÅË¡¤ò¿®¤¸¤Æ¤·¤Þ¤Ã¤Æ¡¢¡ÊÀöǾ¤µ¤ì¤Æ¡©¡Ë
¼è¤êÊÖ¤·¤Î¤Ä¤«¤Ê¤¤¾õÂ֤˴٤äƤ·¤Þ¤¦ÉÔ¹¬¤Ê´µ¼Ô¤µ¤ó¤â¸ºß¤¹¤ë¤³¤È¤Ç¤¹¡£
¤³¤ì¤Ï¸½ºß¤ÎÆüËܤÎÂåÂØÎÅË¡¤ò¹Í¤¨¤ë¾å¤ÇÈó¾ï¤ËÂ礤ÊÌäÂê¤À¤È»×¤¤¤Þ¤¹¡£
¤¤Ã¤ÈËÜÅö¤Ë´µ¼Ô¤µ¤ó¤Î¤¿¤á¤Ë¤Ê¤ëÂåÂØÎÅË¡¤â¤¢¤ë¤Î¤«¤âÃΤì¤Þ¤»¤ó¡£
¤·¤«¤·¡¢°ìÉô¤Î¶¯Íߤʥ¬¥ó¥Ó¥¸¥Í¥¹¥Þ¥ó¤¬¡¢
¤¹¤Ù¤Æ¤ò¥À¡¼¥Æ¥£¡¼¤Ê¥¤¥á¡¼¥¸¤Ë¤·¤Æ¤·¤Þ¤Ã¤Æ¤¤¤ë¤Î¤«¤âÃΤì¤Þ¤»¤ó¡£
ËÜÆü¤Ï¡¢ÂåÂØÎÅË¡¤Ë¤Ä¤¤¤Æ¤Î¥³¥á¥ó¥È¤òĺ¤¤Þ¤·¤¿¤Î¤Ç¡¢
»ä¤Î¹Í¤¨¤ò½ñ¤¤Þ¤·¤¿¡£
°Ê¾å¡¡Ê¸ÀÕ¡¡¡¡Çßß· ½¼
´µ¼Ô¤µ¤ó¤ÎÃæ¤Ë¤Ï¡¢
¹â³Û¤Ê¼£ÎÅÈñ¤ò»Ùʧ¤¨¤Ð¡¢
¥ê¥ó¥ÑµåÎÅË¡¤ä¤¤¤«¤¬¤ï¤·¤¤Ìȱּ£ÎŤʤɤǡ¢
ÉûºîÍѤÎ̵¤¤¼£ÎŤò¼õ¤±¤ë¤³¤È¤¬¤Ç¤¤ë¡£
»ä¤Ï¡¢¤ª¶â¤¬¤¢¤ë¤«¤é¤½¤Î¤è¤¦¤ÊÆÃ¸¢Åª¤Ê¼£ÎŤò¼õ¤±¤ë¤³¤È¤¬¤Ç¤¤ë¡£
½î̱¤Î¶ì¤·¤ß¤ÏÌ£¤ï¤ï¤Ê¤¯¤Æ¤âÂç¾æÉס£
¤Ê¤É¤È¡¢Â礤ʴª°ã¤¤¤ò¤µ¤ì¤Æ¤¤¤ëÊý¤â»þ¡¹¸«¼õ¤±¤Þ¤¹¡£
¤È¤ó¤Ç¤â¤Ê¤¤Ã×̿Ū¤Ê´ª°ã¤¤¤Ç¤¹¡£
¤½¤ì¤ò¼õ¤±¤Æ¡¢
6·î15Æü¤Ë
ÂåÂØÎÅË¡¤ÏËÜÅö¤Ë̵ÂÌ¡©¤Ê¤Î¤Ç¤·¤ç¤¦¤«¡©
¥¢¥á¥ê¥«¤Ç¤ÏÀѶËŪ¤ËÂåÂØÎÅË¡¤â¼è¤êÆþ¤ì¤Æ¼£ÎŤò¹Ô¤Ã¤Æ¤¤¤ë¤Èʹ¤¤Þ¤·¤¿¡£º£¤Þ¤Ç¤Ï¸ú¤«¤Ê¤«¤Ã¤¿¹³¤¬¤óºÞ¤¬ÂåÂØ¼£ÎŤÎÀ®²Ì¤¬½Ð¤Æ¸ú¤¤¤Æ¤¤¿¡ª¤Ê¤ó¤Æ¤³¤È¤Ï¤Ê¤¤¤Î¤Ç¤·¤ç¤¦¤«¡©
¤¹¤Ù¤Æ¤ÎÂåÂØÎÅË¡¤¬¡¢ÌµÂ̤À¤È¤Ï»×¤Ã¤Æ¤¤¤Þ¤»¤ó¡£
µÕ¤Ë¡¢¥¬¥ó¤Î¼ïÎà¤ä¼£ÎÅ¤ÎÆâÍÆ¤Ë¤è¤Ã¤Æ¤Ï¡¢
ɸ½àŪ¹³´âºÞ¼£ÎŤò¼õ¤±¤ë¤¯¤é¤¤¤Ê¤é¤Ð¡¢
ÂåÂØÎÅË¡¤ÎÊý¤¬¥Þ¥·¡£
¤È¹Í¤¨¤ë¤³¤È¤â¤¢¤ë¤¯¤é¤¤¤Ç¤¹¡£
ÂåÂØÎÅË¡¤ÎÌäÂê¤Ï¡¢
2·î12Æü¤Î¡Ö¥¤¥ó¥Á¥Ìȱּ£ÎÅ¥¯¥ê¥Ë¥Ã¥¯¡×
1·î24Æü¤Î¡Ö·ò¹¯¿©ÉʤˤĤ¤¤Æ¡×
1·î22Æü¤Î¡ÖÌȱּ£ÎšפʤɤǤâ½ñ¤¤Þ¤·¤¿¤¬¡¢
¤¢¤¿¤«¤â¿Âç¤Ê¼£ÎŸú²Ì¤¬¤¢¤ë¤«¤Î¤è¤¦¤ËÀëÅÁ¤·¤Æ¡¢
Ë¡³°¤Ê¼£ÎÅÈñ¤òÀÁµá¤¹¤ë¿ÇÎŽê¤Î¸ºß¤Ç¤¹¡£
¥¬¥ó¥Ó¥¸¥Í¥¹¤Ë¤Ò¤¿Áö¤Ã¤Æ¤¤¤ëÇÚ¤¬¤¤¤ë¤³¤È¤Ç¤¹¡£
´µ¼Ô¤µ¤ó¤Î°Õ¼±¤È¤·¤Æ¤Ï¡¢
¡Ö¿³Û¤Î¼£ÎÅÈñ¤ò»Ùʧ¤¨¤Ð¡¢¤½¤Îʬ¤µ¤¾Â礤ʸú²Ì¤¬´üÂԤǤ¤ë¤Î¤Ç¤Ï¤Ê¤¤¤«¡×
¤È¹Í¤¨¤Æ¤·¤Þ¤¦¤Î¤Ç¤Ï¤Ê¤¤¤Ç¤·¤ç¤¦¤«¡£
¤·¤«¤·¡¢¤½¤ÎÍͤʤ³¤È¤Ï¤¢¤ê¤Þ¤»¤ó¡£
5·î19Æü¤Î¡Ö¥À¥á¤â¤È¼£ÎŤȤϡ©¡×¤Ç½ñ¤¤Þ¤·¤¿¤¬¡¢
¸½ºß¤Îɸ½àŪ¹³´âºÞ¼£ÎŤ½¤Î¤â¤Î¤¬¡¢
º¬¼£ÉÔǽ¤Î¥¬¥ó¤ËÂФ·¤Æ¤Ï¡¢
¡Ö¥À¥á¤â¤È¼£ÎšפΤ褦¤Ê¤â¤Î¤Ç¤¹¡£
¤·¤«¤·¡¢É¸½àŪ¹³´âºÞ¼£ÎŤϡ¢
¥À¥á¤À¤Ã¤¿¾ì¹ç¡¢¡Ö¤â¤È¡×¤Ë¤Ï¤Ê¤ê¤Þ¤»¤ó¡£
ɸ½àŪ¹³´âºÞ¼£ÎŤǤϡ¢¥À¥á¤À¤Ã¤¿¾ì¹ç¡¢
½ÐȯÅÀ¡Ö¤â¤È¡×¤Ë¤ÏÌá¤ì¤Þ¤»¤ó¡£
¥Þ¥¤¥Ê¥¹ÅÀ¤«¤é¤ÎºÆ½Ðȯ¤Ë¤Ê¤ê¤Þ¤¹¡£
¤¢¤ë¤¤¤ÏºÆµ¯ÉÔǽ¤Ë¤Ê¤ê¤Þ¤¹¡£
¤½¤ì¤ò¹Í¤¨¤ì¤Ð¡¢
¥µ¥×¥ê¥á¥ó¥È¤òÍѤ¤¤¿ÂåÂØÎÅË¡¤Ï¡¢
¤½¤Î¡Ö¤ª»î¤·»þ´Ö¡×¤À¤±¤ò¸í¤ë¤³¤È¤Ê¤¯¡¢
¿¼Æþ¤ê¤·¤Ê¤±¤ì¤Ð¡¢
¥¼¥í¤«¤é¤ÎºÆ¥¹¥¿¡¼¥È¤¬²Äǽ¤Ç¤¹¤«¤é¡¢
¡Ö¥À¥á¤â¤È¡×¤Ç¤¢¤ê¡¢°¤¯¤Ï¤Ê¤¤¤È»×¤¤¤Þ¤¹¡£
»ä¼«¿È¤Ï¡¢ÂåÂØÎÅË¡¤Ï¹Ô¤Ã¤Æ¤¤¤ë¤Ä¤â¤ê¤Ï¤¢¤ê¤Þ¤»¤ó¤¬¡¢
¡Öɸ½àŪ¹³´âºÞ¼£ÎŤòÍ£°ìÀµÅö¤Ê¥¬¥ó¼£ÎšפÀ¤È¹Í¤¨¤Æ¤¤¤ë¥»¥ó¥»¥¤Êý¤«¤é¤ß¤ì¤Ð¡¢
»ä¤Î¡Öɸ½àŪ¤Ç¤Ï¤Ê¤¤¹³´âºÞ¼£ÎšפâÂåÂØÎÅË¡¤Î°ì¤Ä¤È¸«¤é¤ì¤Æ¤¤¤ë¤«¤â¤·¤ì¤Þ¤»¤ó¡£
¤Þ¤¿¡¢ÂåÂØÎÅË¡¤È¤Ï°ã¤¤¤Þ¤¹¤¬¡¢
ɸ½àŪ¤Ç¤Ï¤Ê¤¤¶Ë¾¯Î̤ι³´âºÞ¼£ÎŤò¹Ô¤Ê¤¦¤È¤¤Ë¡¢
ÌȱֳèÀ¤òÁý¶¯¤µ¤»¤ë¥µ¥×¥ê¥á¥ó¥È¤òÊ»ÍѤ¹¤ë¤³¤È¤Ë¤è¤Ã¤Æ¡¢
Â礤ʸú²Ì¤ò¤ß¤ë¤È¤¤¤¦¤³¤È¤Ï¡¢²¿²ó¤â·Ð¸³¤·¤Æ¤ª¤ê¤Þ¤¹¡£
¤Þ¤¿¡¢¥µ¥×¥ê¥á¥ó¥È¤¬²¿¸Î¤«¹³´âºÞ¼£ÎŤÎÉûºîÍѤò·Ú¸º¤¹¤ë¤È¤¤¤¦»ö¼Â¤Ï¡¢
¤·¤Ð¤·¤Ð·Ð¸³¤·¤Þ¤¹¡£
¤³¤ì¤Ï¡¢Â¾¤Îɱ¡¤Çɸ½àŪ¹³´âºÞ¼£ÎŤò¼õ¤±¤¿´µ¼Ô¤µ¤ó¤Î´¶ÁۤǤ¹¡£
¤½¤Î¥µ¥×¥ê¥á¥ó¥È¤¬´µ¼Ô¤µ¤ó¤Î·ÐºÑŪ¤ÊÉéô¤Ë¤Ê¤é¤Ê¤¤¤Î¤Ç¤¢¤ì¤Ð¡¢
¤±¤Ã¤·¤Æ°¤¯¤Ê¤¤¤È¹Í¤¨¤Æ¤¤¤Þ¤¹¡£
¼ÂºÝ¤Ë¥Ï¡¼¥»¥×¥Á¥ó¤ä´Ö¤â̵¤¯ÆüËܤǤâ½Ð¤Æ¤¯¤ë¥¢¡¼¥Ó¥¿¥Ã¥¯¥¹¤Ê¤É¤Ç¤Ï¡¢
ADCC¡ÊAntibody Dependent Cell Mediated Cytotoxity¡Ë
¹³Âΰ͸ÀºÙ˦¾ã³²ºîÍѤȤ¤¤¦¡¢
ÌȱֺÙ˦¤¬Â¸ºß¤·¤Æ¤Ï¤¸¤á¤Æ¹³¼ðáç¸ú²Ì¤òȯ´ø¤¹¤ë¤³¤È¤¬È½¤Ã¤Æ¤¤¤ëÌôºÞ¤â¤¢¤ê¤Þ¤¹¡£
¸½¼Â¤Ë¤Ï¥Ï¡¼¥»¥×¥Á¥ó¤ò»È¤¦¤È¤¡¢¤½¤ÎADCC³èÀ¤Ï¤Þ¤Ã¤¿¤¯¹Í褵¤ì¤º¡¢
ÌȱÖÎϤʤɴ°Á´¤Ë»¦¤·¤Æ¤·¤Þ¤¦Ç»Å٤ι³´âºÞ¤¬Ê»ÍѤµ¤ì¤Æ¤¤¤Þ¤¹¤¬¡¢
Ť¯À¸¤¤ë¡¢¤·¤«¤â¤Ä¤é¤¤»×¤¤¤ò¤·¤Ê¤¤¤³¤È¤ò¹Í¤¨¤ë¤È¡¢
¥Ï¡¼¥»¥×¥Á¥ó¤Î»È¤¤Êý¤Ï¡¢ºÆ¹Í¤ÎɬÍפ¬¤¢¤ë¤È»×¤Ã¤Æ¤¤¤Þ¤¹¡£
ÌÞÏÀ¡¢»ä¤Ï¥Ï¡¼¥»¥×¥Á¥ó¤âɸ½àŪ¤Ê¹³´âºÞ¤È¤ÎÊ»ÍѤϹԤʤäƤª¤ê¤Þ¤»¤ó¡£
¤³¤ì¤ò¡¢½ñ¤¯¤ÈŤ¯¤Ê¤ë¤Î¤Ç¸åÆü¤Ë¤·¤Þ¤¹¡£
¤Þ¤¿ºÇ¶á¤Ç¤Ï¡¢Ìȱ֤Ȥϴط¸¤Ê¤¤¤è¤¦¤Ç¤¹¤¬¡¢
¤¢¤ë¥µ¥×¥ê¥á¥ó¥È¤Ç¡¢¥¬¥ó¤ÎÁý¿£ÍÞÀ©¸ú²Ì¤¬¤¢¤ë¤«¤âÃΤì¤Ê¤¤¤³¤È¤¬È½¤ê¤Þ¤·¤¿¡£
¤Þ¤À¶Ë¤á¤ÆÉԳμ¤ʥǡ¼¥¿¤Ç¤¹¤¬¡¢
ËÜÅö¤ËÁý¿£ÍÞÀ©¸ú²Ì¤¬Ç§¤á¤é¤ì¤ë¤Î¤Ç¤¢¤ì¤Ð¡¢
͸ú¤Ê¼£ÎżêÃʤˤʤë²ÄǽÀ¤¬¤¢¤ê¤Þ¤¹¡£
º£¸å¤âÂåÂØÎÅË¡¤ò¹Ô¤Ã¤Æ¤¤¤¯¤Ä¤â¤ê¤Ï¤Þ¤Ã¤¿¤¯¤¢¤ê¤Þ¤»¤ó¤¬¡¢
͸ú¤Ç¤¢¤ê¡¢¿ÈÂΤ˳²¤¬¤Ê¤¤¡¢¤µ¤é¤Ë
·ÐºÑŪ¾ò·ï¤â´Þ¤á¤ÆQOL¤òÄã²¼¤µ¤»¤Ê¤¤¼£ÎŤǤ¢¤ì¤Ð¡¢
²¿¤Ç¤â¼è¤êÆþ¤ì¤Æ¤¤¤¯¤Ä¤â¤ê¤Ç¤¹¡£
»ä¤Ë¤È¤Ã¤Æ¤Î¥¨¥Ó¥Ç¥ó¥¹¤ÏÌܤÎÁ°¤Î´µ¼Ô¤µ¤ó°ì¿Í°ì¿Í¤¹¤Ù¤Æ¤Ç¤¹¡£
¡Ö¥¢¥á¥ê¥«¤ÇÂåÂØÎÅË¡¤¬À¹¤ó¡×¤È¤Î¤´»ØÅ¦¤Ç¤¹¤¬¡¢
»ä¤Ï¸½ºß¤Î¥¢¥á¥ê¥«¤Î¥¬¥ó¼£ÎŤξõ¶·¤ÏÃΤê¤Þ¤»¤ó¡£
¤·¤«¤·¡¢ÀèÆü½ªÎ»¤·¤¿ASCO¡ÊÊÆ¹ñÎ×¾²¥¬¥ó³Ø²ñ¡Ë¤Ç¤Ï¡¢
ÂåÂØÎÅË¡¤ÎÏÃÂ꤬½Ð¤Æ¤¤¤¿¤È¤Ïʹ¤¤¤Æ¤¤¤Þ¤»¤ó¡£
1987ǯ¤«¤é89ǯ¤Î2ǯ´Ö¸«¤Æ¤¤¿¥¢¥á¥ê¥«¤Î¥¬¥ó¼£ÎŤˡ¢
ÂåÂØÎÅË¡¤¬¹Ô¤ï¤ì¤Æ¤¤¤ë¤È¤¤¤¦Ïäâʹ¤¤¤¿¤³¤È¤Ï¤¢¤ê¤Þ¤»¤ó¡£
¤à¤·¤íÆüËÜ¤ÎÆüËÜ´â¼£Îųزñ¤Ç¤Ï¡¢
O¥¤¥ó¥Á¥Ìȱּ£ÎÅ¥¯¥ê¥Ë¥Ã¥¯¤ÎË¿¸µ¶µ¼ø¤¬¡¢
ÆüËÜ´â¼£Îųزñ¤òÀëÅÁ¤ËÍøÍѤ·¤Æ¤¤¤¿¤È¤¤¤¦»ö¼Â¤¬¤¢¤ê¡¢
°ìºòǯ¤«¤é¡¢°ìÀÚ¼è¤ê¾å¤²¤é¤ì¤Ê¤¯¤Ê¤ê¤Þ¤·¤¿¤¬¡¢
¤½¤ì¤Þ¤Ç¤Ï¡¢¥¢¥¬¥ê¥¯¥¹¤ä¡¢¥ê¥ó¥ÑµåÎÅË¡¤Ê¤É¤Î
ÂåÂØÎÅË¡¤Î±éÂ꤬Ëèǯ¤¿¤¯¤µ¤ó½Ð¤µ¤ì¤Æ¤¤¤Þ¤·¤¿¡£
ÂåÂØÎÅË¡¤Ï¡¢ÆüËܤÎÊý¤¬À¹¤ó¤Ê¤Î¤«¤âÃΤì¤Þ¤»¤ó¡£
²¿ÅÙ¤âÅö¥Ö¥í¥°¤Ç¤â»ØÅ¦¤·¤Æ¤¤¤ë¤È¤ª¤ê¡¢
¥¢¥á¥ê¥«¤Ï¡¢ÆüËܤȰåÎÅÀ©ÅÙ¤¬Â礤¯°ã¤¤¤Þ¤¹¡£
4000Ëü¿Í¤â¤¤¤ë̵Êݸ±¼Ô¤Ï¡¢
¼«Ê¬¤Î˾¤à°åÎŤϼõ¤±¤é¤ì¤Þ¤»¤ó¡£
¤½¤ÎÊý¡¹¤¬Î÷²Á¤ÊÂåÂØÎÅË¡¤ËÍê¤Ã¤Æ¤¤¤ë¤è¤¦¤Êµ¤¤¬¤·¤Þ¤¹¡£
¹³´âºÞ¼£ÎŤò̵Êݸ±¤Ç¹Ô¤Ê¤Ã¤¿¾ì¹ç¶Ë¤á¤Æ¹â³Û¤Ë¤Ê¤ê¤Þ¤¹¡£
ÆüËܤȤϻö¾ð¤¬°ã¤¦¤Î¤Ç¤Ï¤Ê¤¤¤Ç¤·¤ç¤¦¤«¡£
º£¤ÎÆüËܤÎÂåÂØÎÅË¡¤Ï¡¢Àè¤Û¤É¤Î¥¬¥ó¥Ó¥¸¥Í¥¹¤ÎÌäÂê¡£
¹¹¤Ë¿¼¹ï¤Ê¤Î¤Ï4·î30Æü¤Î¡Ö¥Û¥á¥ª¥Ñ¥·¡¼¡©¡×¤Ç¤â½ñ¤¤¤¿¤È¤ª¤ê¡¢
ÂåÂØÎÅË¡¤ò¿®¤¸¤Æ¤·¤Þ¤Ã¤Æ¡¢¡ÊÀöǾ¤µ¤ì¤Æ¡©¡Ë
¼è¤êÊÖ¤·¤Î¤Ä¤«¤Ê¤¤¾õÂ֤˴٤äƤ·¤Þ¤¦ÉÔ¹¬¤Ê´µ¼Ô¤µ¤ó¤â¸ºß¤¹¤ë¤³¤È¤Ç¤¹¡£
¤³¤ì¤Ï¸½ºß¤ÎÆüËܤÎÂåÂØÎÅË¡¤ò¹Í¤¨¤ë¾å¤ÇÈó¾ï¤ËÂ礤ÊÌäÂê¤À¤È»×¤¤¤Þ¤¹¡£
¤¤Ã¤ÈËÜÅö¤Ë´µ¼Ô¤µ¤ó¤Î¤¿¤á¤Ë¤Ê¤ëÂåÂØÎÅË¡¤â¤¢¤ë¤Î¤«¤âÃΤì¤Þ¤»¤ó¡£
¤·¤«¤·¡¢°ìÉô¤Î¶¯Íߤʥ¬¥ó¥Ó¥¸¥Í¥¹¥Þ¥ó¤¬¡¢
¤¹¤Ù¤Æ¤ò¥À¡¼¥Æ¥£¡¼¤Ê¥¤¥á¡¼¥¸¤Ë¤·¤Æ¤·¤Þ¤Ã¤Æ¤¤¤ë¤Î¤«¤âÃΤì¤Þ¤»¤ó¡£
ËÜÆü¤Ï¡¢ÂåÂØÎÅË¡¤Ë¤Ä¤¤¤Æ¤Î¥³¥á¥ó¥È¤òĺ¤¤Þ¤·¤¿¤Î¤Ç¡¢
»ä¤Î¹Í¤¨¤ò½ñ¤¤Þ¤·¤¿¡£
°Ê¾å¡¡Ê¸ÀÕ¡¡¡¡Çßß· ½¼



